DescriptionAgomelatine is a novel antidepressant with a dual mechanism of action as a melatonin receptor agonist (MT?/MT?) and serotonin 5-HT?C receptor antagonist. It is widely studied in research involving mood regulation, neurogenesis, sleep-wake cycles, and chronobiology. Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications 4 Safety & Handling 5 Research Use Disclaimer Product SpecificationsParameterDetailsProduct NameAgomelatine TabletsBrand NamePusikeActive IngredientAgomelatineCAS Number138112-76-2Molecular FormulaC15H17NO2Molecular Weight243.3 g/molStrength25?mg per tabletFormulationOral tabletsPack Size14 tablets per boxApproval NumberH20249128 (NMPA, China)Drug Code86904111000617ManufacturerShandong Jingwei Pharmaceutical Co., Ltd.Storage ConditionsStore in a cool, dry place (15–25°C); protect from lightResearch UseLaboratory research onlyMechanism of ActionAgomelatine exhibits a dual mechanism:Agonist at MT? and MT? receptors, promoting circadian rhythm normalization.Antagonist at 5-HT?C receptors, resulting in increased dopamine and norepinephrine release in the frontal cortex.This unique action is useful in research models of depression, sleep disturbance, and neurochemical imbalance.Research ApplicationsDepression & Mood DisordersUsed in preclinical models simulating major depressive disorder (MDD) and seasonal affective disorder (SAD).Sleep-Wake Cycle StudiesImproves sleep onset and continuity in animal circadian disruption models.Neuroplasticity & BDNFShown to upregulate BDNF expression, supporting studies on neuroregeneration.Non-serotonergic Antidepressant ResearchUseful for investigating alternative antidepressant pathways without SSRI-like adverse effects.Safety & HandlingHandling: Use gloves and protective equipment. Avoid direct contact with tablet powder.Storage: Keep sealed at room temperature. Protect from humidity.Stability: Shelf-stable for up to 36 months under recommended conditions.Toxicology: At high doses in lab settings, may cause hepatotoxic effects—handle with caution in long-term studies.Research Use DisclaimerThis product is intended exclusively for laboratory research purposes. It is not approved for human, clinical, or veterinary application. Users must follow institutional guidelines and local laws. Improper use may result in serious health risks.
