Description Contents hide 1 Product Description 2 Product Specifications 3 Mechanism of Action & Research Applications 4 Precautions 4.1 Disclaimer Product DescriptionAbaloparatide is a synthetic peptide analog developed for scientific research related to parathyroid hormone type 1 receptor (PTH1R) signaling pathways. Owing to its selective receptor interaction profile, this peptide is widely used in experimental models investigating bone formation, calcium homeostasis, and endocrine signaling mechanisms.In research environments, Abaloparatide serves as a valuable molecular tool for studying receptor activation dynamics, downstream signaling cascades, and structure–activity relationships associated with parathyroid hormone–related peptides. Its defined amino acid sequence and predictable physicochemical behavior enable reproducible outcomes across in vitro and in vivo experimental systems.The peptide demonstrates preferential activation of specific PTH1R conformations, which makes it particularly relevant for mechanistic studies focused on anabolic signaling pathways in skeletal biology. Researchers frequently employ this compound to differentiate transient versus sustained receptor activation patterns and their biological consequences.Supplied as a high-purity raw material, Abaloparatide supports flexible experimental design, including custom formulation, controlled reconstitution, and dose-response investigations. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and batch-to-batch consistency suitable for advanced research use.Product SpecificationsItemDescriptionProduct NameAbaloparatideSynonymsPTHrP (1–34) analogCAS Number247062-33-5Molecular FormulaC174H300N56O49Molecular Weight~3960.6 g/molAmino Acid SequenceSynthetic peptide (34 amino acids)Peptide TypeLinear synthetic peptideFormLyophilized powderPurity≥99% (HPLC)Strength OptionsCustomizable (mg scale)AppearanceWhite to off-white powderIdentity VerificationHPLC, MSSolubilitySoluble in water or suitable buffersPackagingSterile glass vialStorage Condition−20 °C, protected from lightIntended UseResearch use onlyMechanism of Action & Research ApplicationsAbaloparatide selectively binds to the parathyroid hormone receptor 1 (PTH1R), triggering signaling pathways that enhance osteoblast activity and bone formation. Its unique receptor binding profile results in rapid activation and internalization, promoting bone anabolism without significant resorption. This mechanism is critical in studying treatments for osteoporosis, fracture healing, and bone regenerative medicine.Research applications include:Osteoporosis disease modelsBone metabolism studiesSkeletal regeneration researchEvaluation of bone anabolic agentsabaloparatide oxidized formulaPrecautionsIn laboratory models, abaloparatide may influence:Bone remodeling markersCellular proliferation of osteoblastsCalcium metabolism in experimental systemsDisclaimerThis product is intended for research use only.Not for human or veterinary use.All handling and experimental applications must comply with applicable laboratory safety and regulatory requirements.
