Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling 4.1 ?? Research?Use Disclaimer Product SpecificationsAttributeDetailsProduct NameFlumazenil InjectionGeneric NameFlumazenil (Ethyl 8?fluoro?5?methyl?6?oxo?5,6?dihydro?4H?imidazo[1,5?a][1,4]benzodiazepine?3?carboxylate)CAS Number78755?81?4Molecular FormulaC??H??FN?O?Molecular Weight303.29?g/molDosage FormSterile injectable solution (IV use)Strength0.1?mg/mL (1?mg per 10?mL vial)Pack Size1 vial per boxApproval NumberH20243371 (China NMPA)Product Code86983450000045ManufacturerSichuan Meidakang Jiale Pharmaceutical Co., Ltd.StorageStore at controlled room temperature; protect from lightIntended UseLaboratory research onlyMechanism of ActionFlumazenil competitively binds at the benzodiazepine recognition site on GABA? receptors, reversing the sedative and CNS?depressant effects of benzodiazepines gutnliver.org 15pubchem.ncbi.nlm.nih.gov 15en.wikipedia.org 15.Research Applications & PharmacologySedation reversal models: Useful in controlled reversal of benzodiazepine-induced CNS depression in animal studies pdf.hres.ca 12ncbi.nlm.nih.gov 12en.wikipedia.org 12.Pharmacokinetics:Onset in 1–2 minutes; peak effect at 6–10 minutes; duration ~19–50 minutes depending on dose and benzodiazepine type .Eliminated primarily by the liver; terminal half-life ~40–80 minutes; excretion is ~90–95% renal, ~5–10% fecal .Safety Profile & HandlingAdverse events: Possible seizures, resedation, transient anxiety, nausea; caution in benzodiazepine-dependent models .Contraindications (in research): Avoid in subjects predisposed to seizure, with co-administration of TCA, or prolonged benzodiazepine exposure .Handling tips: Administer slowly IV (2?mL per 15?s); monitor neuromotor and respiratory function; have emergency protocols ready .?? Research?Use DisclaimerThis product is intended solely for laboratory research use. It is not approved for therapeutic, diagnostic, clinical, or veterinary applications. Misuse may pose significant risks and affect experimental integrity.
