Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling 4.1 ?? Research?Use Disclaimer Product SpecificationsAttributeDetailsProduct NameDrotaverine Hydrochloride InjectionGeneric NameDrotaverine HydrochlorideCAS Number985?12?6 Molecular FormulaC??H??NO? · HClMolecular Weight~433.97?g/molDosage FormSolution for IM/IV injectionStrength40?mg per 2?mL vialPack Size5 vials per boxApproval No.H20183353 (China NMPA)Product Code86909568000197ManufacturerChongqing Shenghuaxi Pharmaceutical Co., Ltd.Barcode6933982500616StorageStore at 2–8?°C, protect from lightIntended UseLaboratory research use onlyMechanism of ActionDrotaverine selectively inhibits phosphodiesterase?4 (PDE4) and blocks L-type calcium channels, leading to smooth muscle relaxation without anticholinergic side effects. Useful in studies involving colic, dysmenorrhea, and uterine dilation.Research Applications & PharmacologySmooth muscle spasm models: Effective in gastrointestinal, genitourinary, biliary, and uterine muscle studies (e.g., labor augmentation, renal colic relief)?go.drugbank.com.Pharmacokinetics: High bioavailability (~65%), peak effect in 45–60 min, long half-life (7–16?hrs), 95–98% protein bound, hepatic elimination, urinary and biliary excretion?medchemexpress.com 2en.wikipedia.org 2clinicaltrials.gov 2.Safety Profile & HandlingAdverse Effects:Possible dizziness, headache, flushing, hypotension, tachycardia, rare arrhythmia/anaphylaxis.Overdose can lead to AV block, respiratory depression, seizures, cardiac arrest.Handling Guidelines:Use PPE, aseptic technique.Administer slowly via IM/IV; aspirate to avoid intravascular injection.Monitor animals for cardiovascular and CNS responses.Dispose of vials as pharmaceutical waste.?? Research?Use DisclaimerThis product is intended solely for laboratory research and not approved for diagnosis, therapy, clinical, or veterinary use. Misuse may cause safety hazards and compromise scientific data.
