Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling 4.1 ?? Research?Use Disclaimer Product SpecificationsAttributeDetailsProduct NameDiclofenac Sodium Enteric-Coated Tablets (Renhe®)Generic NameDiclofenac SodiumCAS Number15307?86?5Molecular FormulaC??H??Cl?NNaO?Molecular Weight~296.15?g/molDosage FormEnteric-coated oral tabletStrength25?mg per tabletPack Size72 tablets per box (3 × 24)Approval NumberH41022227 (China NMPA)Product Code86903081000221ManufacturerBaiyunshan Dongtai Shandong Pharmaceutical Co., Ltd.Barcode6922670003720StorageStore at 15–25?°C, dry environmentIntended UseLaboratory research use onlyMechanism of ActionDiclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX?1 and COX?2 enzymes, blocking prostaglandin synthesis and reducing inflammation, pain, and fever. The enteric coating delays release until the tablet reaches the intestine to reduce gastric side effects. en.wikipedia.org 1pubchem.ncbi.nlm.nih.gov 1dailymed.nlm.nih.govResearch Applications & PharmacologyInflammation & pain models: Commonly used in arthritis, muscle, joint pain, and migraine researchPharmacokinetics: Well-absorbed; undergoes first-pass metabolism via CYP2C9/CYP3A4; half-life ~1.2–2?hrs; >99% protein-bound; excreted in urine and bileFormulation benefits: Enteric-coating protects from acid degradation and gastric irritation; dissolution occurs in the intestineSafety Profile & HandlingPreclinical and clinical insights:Gastrointestinal: risk of bleeding, ulceration, perforationCardiovascular: increased risk of thrombotic events such as MI and strokeOther effects: renal impairment, fluid retention, elevated liver enzymes, hypersensitivity reactionsHandling tips:Administer orally with water or food in animal modelsMonitor for GI, renal, hepatic, and cardiovascular markersWear PPE and dispose of unused tablets as chemical waste?? Research?Use DisclaimerThis product is intended solely for laboratory research purposes. It is not approved for any therapeutic, diagnostic, clinical, or veterinary use. Improper use may pose hazards and compromise research data integrity.
