Ciprofol 50?mg /?20?mL ×?5 vials – Wholesale price comparison Research Use Only

Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling Product SpecificationsAttributeDetailsProduct NameCiprofol Injection (Haisco®)Generic NameCiprofol (R?2?(1?cyclopropylethyl)?6?isopropylphenol)CAS Number1637741?58?2 en.wikipedia.org 12en.wikipedia.org 12pmc.ncbi.nlm.nih.gov 12Molecular FormulaC??H??OMolecular Weight~212 g/mol (approximate for formula)Dosage FormSterile oil?in?water emulsion for IV injectionStrength50?mg per 20?mL vial (10?mg/mL)Pack Size5 vials per boxApproval NumberChina NMPA H20200013Product Code86906155000394ManufacturerLiaoning Haisco Pharmaceutical Co., Ltd.Storage ConditionsStore at 2–25?°C; shield from light; shake well before useIntended UseLaboratory and preclinical research onlyMechanism of ActionCiprofol acts as a selective GABAA_AA? receptor agonist, enhancing inhibitory neurotransmission. It binds more strongly than propofol, giving it 4–6× higher potency.Research Applications & PharmacologyAnesthesia & Sedation Models: Used in induction and maintenance protocols—with typical bolus doses of 0.2–0.5?mg/kg—demonstrating efficacy non-inferior to propofol in various clinical settings.Preclinical Neuropharmacology: Ideal for mechanistic studies on sedation, analgesia, hemodynamics, and cardiac protection .Comparative Efficacy: RCTs in GI endoscopy and gynecological procedures found similar sedation success to propofol but with reduced adverse events and injection pain.Pharmacokinetics: Rapid onset (~1–2?min), short duration, primarily metabolized via liver glucuronidation, renal excretion .Safety Profile & HandlingAdverse Events: Lower incidence of injection site pain and hypotension compared to propofol.Handling: Use aseptic technique; single-use vial; discard unused portion per protocols; inspect emulsion before use.Contraindications & Precautions: Potent sedation; monitor respiratory and cardiovascular status closely in vivo studies.Storage: Maintain 2–25?°C, away from light. Emulsion remains stable under recommended conditions.