Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling 4.1 ?? Research?Use Disclaimer Product SpecificationsAttributeDetailsProduct NameCelecoxib CapsulesGeneric NameCelecoxibCAS Number169590?42?5Molecular FormulaC??H??F?N?O?SMolecular Weight~381.37?g/molDosage FormOral capsuleStrength200?mg per capsulePack Size(e.g., 30 capsules)Manufacturing ApprovalN/A (research grade)ManufacturerSichuan Xinston PharmaceuticalStorageStore at 15–25?°C, protect from moisture and lightIntended UseLaboratory research use onlyMechanism of ActionCelecoxib selectively inhibits cyclooxygenase?2 (COX?2), reducing prostaglandin synthesis involved in inflammation, pain, and fever—while sparing COX?1, reducing gastrointestinal side effects in research models.zh.wikipedia.orgaccessdata.fda.gov 2de.wikipedia.org 2zh.wikipedia.org 2dailymed.nlm.nih.govncbi.nlm.nih.gov 1medcentral.com 1Research Applications & PharmacologyInflammation & pain models: Used in osteoarthritis, rheumatoid arthritis, nociceptive pain, and dysmenorrhea studies.Cancer/prevention models: Investigated for chemoprevention in familial adenomatous polyposis and COX?2?dependent tumor biology (e.g., colorectal, neuroblastoma). Cardiovascular risk profiling: Employed in studies assessing thrombotic risk and COX?2 inhibitor safety. Pharmacokinetics: Well absorbed, peak plasma 2–4 hrs, half-life ~6–12 hrs, highly protein?bound (~97%), metabolized by CYP2C9/CYP3A4 to inactive metabolites excreted in urine/feces. Safety Profile & HandlingCommon adverse effects (clinical/preclinical context):GI: bleeding, ulceration, perforationCardiovascular: increased risk of MI and strokeOthers: headache, dizziness, hypertension, renal and hepatic effectsLab handling recommendations:Use personal protective equipment and follow standard handling for NSAIDs.Monitor study models for GI, cardiovascular, renal, and hepatic markers.Use lowest effective dose for shortest duration.Dispose of unused material as chemical waste.?? Research?Use DisclaimerThis product is intended solely for laboratory research, and is not approved for therapeutic, diagnostic, clinical, or veterinary applications. Misuse may pose safety risks and compromise data integrity.
