DescriptionAlfosbuvir is a nucleotide prodrug that, once metabolized in cells, inhibits HCV NS5B RNA-dependent RNA polymerase—blocking viral replication across multiple genotypes. As China’s first domestic innovative HCV NS5B inhibitor with independent IP, it has shown promising efficacy in phase III trials—especially in combination with daclatasvir—for genotypes?1, 3, and 6, even among cirrhotic patients. Contents hide 1 Alfosbuvir Tablets Product Specifications 2 Alfosbuvir Tablets Mechanism of Action 3 Alfosbuvir Tablets Research Application Areas 4 Safety & Handling 5 Core Keywords 6 Research Use Disclaimer Alfosbuvir Tablets Product SpecificationsParameterDetailsProduct NameAlfosbuvir Tablets (Sanoldi®)Generic NameAlfosbuvirCAS Number(Not available publicly)Molecular Formula(Proprietary; nucleotide analogue)Dosage FormOral film-coated tabletStrength100?mg per tabletPack Size42 tablets per bottleApproval NumberH20230010ManufacturerNanjing Sanhe Pharmaceutical Co., Ltd.BarcodeNot yet assigned; consult pharmacist for barcodeStorage ConditionsStore below 30?°C, away from moisture and lightIntended UseLaboratory research—HCV NS5B polymerase inhibition, antiviral assaysAlfosbuvir Tablets Mechanism of ActionAlfosbuvir is metabolized intracellularly into a non-natural nucleotide analogue that competes with natural nucleotides during viral RNA synthesis. This terminates RNA chain extension, effectively inhibiting HCV replication. It’s considered a pan-genotypic NS5B inhibitor with a high viral suppression profile.Alfosbuvir Tablets Research Application AreasAntiviral potency assays: Measuring NS5B inhibition in HCV replicon systemsResistance profiling: Screening for NS5B resistance-associated substitutions (RAS)Combination therapy models: Testing synergy with NS5A/NS3 inhibitorsGenotype-specific studies: Especially effective in GT1/3/6 cohortsPharmacokinetic / cell uptake research: Understanding prodrug activationSafety & HandlingHandling: Use gloves, lab coat, and eye protection; avoid direct contactStorage: Keep sealed below 30?°C, shielded from light and moisturePrecautions: For in vitro or animal model use only in BSL?2 labsDisposal: Dispose of per institutional chemical/biomedical protocolsCore Keywordsalfosbuvir tablets, Sanoldi alfosbuvir, HCV NS5B inhibitor, nucleotide prodrug HCV, antiviral research tablets, H20230010, lab-grade alfosbuvir, pan-genotypic HCV DAAResearch Use DisclaimerThis product is intended exclusively for laboratory and preclinical research use. It is not approved for clinical, therapeutic, diagnostic, or veterinary use. Misuse may trigger legal and health consequences. Use only under approved institutional protocols.
