Epalrestat Tablets 50mg – For Laboratory Research Use Only

DescriptionEpalrestat is an aldose reductase inhibitor (ARI) widely used in laboratory models investigating diabetic neuropathy, oxidative stress, and nerve conduction velocity. It plays a key role in research related to the polyol pathway, particularly under hyperglycemic conditions.This formulation by Hebei Ruisen Pharmaceutical delivers 50mg per tablet and is ideal for in vitro and in vivo studies evaluating nerve protection and metabolic regulation in diabetic environments.?? This product is for laboratory research use only. Not for human or veterinary consumption. Contents hide 1 Product Specifications 2 Mechanism & Research Applications 3 Observed Effects in Research Models 4 Safety & Handling 5 Research Use Disclaimer Product SpecificationsParameterDetailsProduct NameEpalrestat TabletsGeneric NameEpalrestatCAS Number82159-09-9Molecular FormulaC??H??NO?SMolecular Weight287.33 g/molDosage FormTabletStrength50mg per tabletPackaging[To be confirmed – typically 10–30 tablets]Approval NumberH20253680 (NMPA China)Product Code86902606000418ManufacturerHebei Ruisen Pharmaceutical Co., Ltd.Storage ConditionsStore below 25°C in a cool, dry placeIntended UseLaboratory research onlyMechanism & Research ApplicationsEpalrestat inhibits aldose reductase, the key enzyme in the polyol pathway, which converts glucose to sorbitol. Under hyperglycemia, excess sorbitol contributes to nerve damage and oxidative stress. By blocking this conversion, epalrestat is valuable in exploring neuroprotective strategies for diabetic peripheral neuropathy (DPN).It is commonly used in:Diabetic neuropathy simulation in rodent modelsStudies on nerve conduction velocity and oxidative stressAldose reductase inhibition profilingEvaluation of glucose toxicity in endothelial cellsSynergistic studies with insulin sensitizersObserved Effects in Research ModelsResearch has shown that epalrestat:Improves nerve conduction velocity in diabetic rodentsReduces sorbitol accumulation in nerves and tissuesAttenuates oxidative damage and improves antioxidant enzyme activityEnhances vascular function in high-glucose conditionsSafety & HandlingUse Restriction: For research use onlyProtective Equipment: Gloves, goggles, and lab coat recommendedStorage: Keep sealed and stored below 25°C, away from humidityDisposal: Dispose in accordance with chemical safety protocolsResearch Use DisclaimerThis product is strictly intended for laboratory research use only. It is not for human consumption or therapeutic application. Misuse may result in legal and health consequences. Handle with standard lab safety precautions.