DescriptionBrolucizumab is a humanized single-chain antibody fragment (scFv) targeting vascular endothelial growth factor A (VEGF-A). It is used in ophthalmological research to study mechanisms of wet age-related macular degeneration (wet AMD) and retinal vascular permeability.Beovu delivers high molar concentration of anti-VEGF activity in a compact 27.6mg/0.23ml dosage form, enabling researchers to model retinal neovascularization, angiogenesis inhibition, and anti-VEGF pathways in both in vitro and in vivo settings.?? This product is strictly intended for laboratory research use and is not approved for human or veterinary administration. Contents hide 1 Product Specifications 2 Mechanism & Research Applications 3 Observed Effects in Research Models 4 Safety & Handling 5 Research Use Disclaimer Product SpecificationsParameterDetailsProduct NameBrolucizumab Injection (Beovu)Generic NameBrolucizumabCAS Number1612181-62-6Molecular FormulaNot applicable (monoclonal antibody fragment)Molecular Weight~26 kDaDosage FormInjection (lyophilized or liquid vial)Strength27.6mg in 0.23mlQuantity1 vial per boxApproval NumberSJ20250019 (China NMPA)Product Code86978679002796Barcode86978679002796ManufacturerAlcon-Couvreur N.V. (Belgium)Intended UseFor laboratory research onlyStorageStore refrigerated at 2–8°C; do not freeze or shakeMechanism & Research ApplicationsBrolucizumab binds VEGF-A with high affinity, preventing interaction with VEGF receptors on endothelial cells, thereby suppressing angiogenesis and vascular leakage. It enables researchers to investigate:Pathogenesis and treatment of wet age-related macular degeneration (wet AMD)Experimental retinal angiogenesis modelsComparative efficacy of anti-VEGF agentsVEGF pathway inhibition and downstream signalingOcular pharmacokinetics of antibody fragmentsObserved Effects in Research ModelsIn preclinical studies, Brolucizumab has shown:Potent inhibition of neovascularizationReduction in retinal thickness and fluid accumulationMinimal systemic exposure due to small molecular sizeTransient inflammation in animal eye models (dose-dependent)Appropriate research protocols and animal care guidelines should be followed.Safety & HandlingUse Restriction: Laboratory research use only.Personal Protective Equipment: Gloves, goggles, lab coatStorage: Refrigerate (2–8°C); avoid freezingDisposal: Dispose of biological waste per local biosafety guidelinesResearch Use DisclaimerThis product is strictly intended for laboratory research use only. It is not for clinical, therapeutic, diagnostic, or veterinary use. Misuse may result in legal or health risks. Always follow institutional biosafety and handling protocols.
