Vardenafil Hydrochloride Tablets 20mg Wholesale price comparison

Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling Product SpecificationsAttributeDetailsProduct NameVardenafil Hydrochloride Tablets (Guan’ai® / Qing Doctor)Generic NameVardenafil HydrochlorideCAS Number224785904 (free base) / 330808-88-3 (HCl trihydrate) access.portico.org 12en.wikipedia.org 12accessdata.fda.gov 12Molecular FormulaC-H-N-O-S · HCl · 3HO (trihydrate)Molecular Weight~579.1g/mol (trihydrate)Dosage FormFilm-coated oral tabletStrength20?mg per tabletPack Size5 tablets per box (1 blister pack)Approval No.China NMPA H20244792Product Code86904339000956ManufacturerAnhui Pioneer Pharmaceutical Co., Ltd.Barcode6953780000446StorageStore at 15–25°C; protect from light and moistureIntended UseLaboratory/preclinical research onlyMechanism of ActionVardenafil selectively inhibits PDE5, preventing cGMP breakdown and amplifying nitric oxide-mediated smooth muscle relaxation—primarily in penile and vascular tissues .Research Applications & PharmacologyErectile Dysfunction & Andrology Models: Extensively utilized in PDE5-targeting studies focused on sexual function and vascular physiology .Cardiovascular & Pulmonary Research: Enables exploration of vasodilatory response and pulmonary hypertension .Pharmacokinetics: Oral bioavailability ~15%; protein binding 95%; liver metabolism via CYP3A4; half-life of 4–5h .Toxicology: Non-carcinogenic up to 100 mg/kg/day in animals; high-dose exposures induced testicular and cardiovascular changes in rodents .Safety Profile & HandlingCommon Effects: Headache, flushing, nasal congestion, back pain, dizziness.Serious Risks: Rare hypotension (especially with nitrates), QT prolongation, priapism .Drug Interactions / Contraindications: Avoid co-administration with nitrates, alpha-blockers, or strong CYP3A4 inhibitors in research protocols .Handling Instructions: Use PPE, store under recommended conditions, discard expired tablets per lab safety guidelines.