Vardenafil Hydrochloride Tablets 20mg

Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling Product SpecificationsAttributeDetailsProduct NameVardenafil Hydrochloride Tablets (Wei?Er?Ting®)Generic NameVardenafil HydrochlorideCAS Number224785-90-4 (base) Molecular FormulaC-H-N-O-S · HCl · 3H-O (trihydrate)Molecular Weight~579.1g/molDosage FormFilm-coated oral tabletStrength20?mg per tabletPack Size4 tablets per boxApproval NumberChina NMPA H20244792Product Code86904339000956ManufacturerAnhui Pioneer Pharmaceutical Co., Ltd.Barcode6953780000415Storage ConditionsStore at 15–25°C; protect from light and moistureIntended UseLaboratory/preclinical research onlyMechanism of ActionVardenafil inhibits PDE5 selectively, preventing cGMP breakdown and enhancing NO-mediated smooth muscle relaxation in penile corpora cavernosa and vasculature.Research Applications & PharmacologyErectile Dysfunction (ED) & Andrology Models: Extensively utilized to study sexual function, vascular physiology, and smooth muscle mechanisms .Cardiovascular & Pulmonary Research: Used to investigate vasodilatory responses and pulmonary hypertension models.Comparative Analysis: Demonstrates higher potency (~0.7nM IC for PDE5) and selectivity over sildenafil and tadalafil .Pharmacokinetics: Oral bioavailability ~15%, protein binding ~95%, hepatic metabolism via CYP3A4, half-life 4–5 hours.Safety Profile & HandlingAdverse Effects: Headache, flushing, nasal congestion, back pain, dizziness; rare hypotension, QT prolongation .Drug Interactions & Contraindications: Avoid use with nitrates, alpha-blockers, or CYP3A4 inhibitors in in vivo studies; monitor cardiovascular parameters .Handling Instructions: Use PPE, store under recommended conditions, discard expired tablets per lab protocols.Lab Safety: Not for human/animal administration; research-only. Discard per institutional biosafety guidelines.