Description Contents hide 1 Sildenafil Citrate Product Specifications 2 Sildenafil Citrate Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling Sildenafil Citrate Product SpecificationsAttributeDetailsProduct NameSildenafil Citrate Tablets (ChiWei®)Generic NameSildenafil CitrateCAS Number171599-83-0Molecular FormulaC-H-N-O-S·C-H-OMolecular Weight~666.7g/molDosage FormOral film-coated tabletsStrength100mg per tabletPack Size3 tablets per blister packApproval No.China NMPA H20203599Product Code86904083000868ManufacturerGuangzhou Langsheng Pharmaceutical Co., Ltd.Barcode6944788133717StorageStore at 15–25°C; protect from light and moistureIntended UseLaboratory and preclinical research use onlySildenafil Citrate Mechanism of ActionSildenafil is a potent, highly selective PDE5 inhibitor. By preventing cGMP breakdown, it enhances NO-mediated smooth muscle relaxation—increasing blood flow in the corpus cavernosum and pulmonary arteries.Research Applications & PharmacologyErectile Dysfunction (ED) Models: Used to study the PDE5 pathway, smooth muscle dynamics, and vascular responses .Pulmonary Hypertension: Investigates vasodilatory effects in pulmonary vasculature; improves exercise performance in models .Cardioprotection: Shows myocardial ischemic preconditioning via NO, PKC/ERK signaling, and mitochondrial KATP channels.Emerging Research: Evaluated for roles in neurologic (#Alzheimer’s) and placental circulation .Pharmacokinetics: Oral bioavailability ~41%, protein binding ~96%, peak action ~30–60?min, half?life 3–4h, metabolized via CYP3A4/CYP2C9; excreted mainly fecally (~80%) and renally (~13%) .Safety Profile & HandlingAdverse Effects: Include headache (>10%), flushing, nasal congestion, dyspepsia, and dizziness .Contraindications: Avoid co-administration with nitrates or alpha-blockers in vivo to prevent severe hypotension .Handling Guidelines: Use PPE; store per guidelines; discard expired tablets as per lab protocols.Special Precautions: Avoid in ocular disease models and use caution with cardiovascular-compromised animals
