Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling Product SpecificationsAttributeDetailsProduct NameDutasteride Soft CapsulesGeneric NameDutasterideCAS Number164656-23-9Molecular FormulaC27H30F6N2O2Molecular Weight528.53 g/molDosage FormOral soft gelatin capsuleStrength0.5 mg per capsulePack Size10 capsules per boxApproval No.China NMPA H20234210Product Code86901503000569ManufacturerJiangsu Wangao Pharmaceutical Co., Ltd.Barcode6938033202990Storage ConditionsStore at 2–8°C or 15–25°C; protect from lightIntended UseLaboratory/preclinical research onlyMechanism of ActionDutasteride is an irreversible inhibitor of both type I and II 5-reductase enzymes, preventing conversion of testosterone to DHT. It reduces serum DHT levels by up to 98%, significantly more than finasteride (~65–70%) .Research Applications & PharmacologyBenign Prostatic Hyperplasia (BPH) Models: Widely used to study prostate volume reduction and LUTS in preclinical contexts .Androgenetic Alopecia (AGA) Models: More effective than finasteride in hair growth studies, especially at 0.5mg dosing .Pharmacokinetics: Oral bioavailability ~60%, protein binding ~99%, metabolized via CYP3A4, elimination half-life ~4–5 weeks, mainly excreted in feces (~40%) .Research Formulation Impact: Soft gelatin capsules offer higher bioavailability than tablets or hard capsules .Safety Profile & HandlingAdverse Effects: Can cause sexual dysfunction, breast tenderness/gynecomastia (~1.3%), depression, and self-harm risks in long-term or high-dose models.Drug Interactions/Contraindications: Avoid use in models with CYP3A4 inhibitors; contraindicated in female and pregnant subjects due to teratogenic risk .Handling Instructions: Wear lab-safe PPE. Store per label instructions. Dispose of per institutional safety protocols.
