Description Contents hide 1 Product Specifications 2 Mechanism of Action 3 Research Applications & Pharmacology 4 Safety Profile & Handling Product SpecificationsAttributeDetailsProduct NameDapoxetine Hydrochloride Tablets (Bongo® / Hongqi Pharmaceutical)Generic NameDapoxetine Hydrochloride (C??H??NO·HCl)CAS Number119356-77-3Molecular FormulaC-H-NO·HCl ©C-H-NO·HClMolecular Weight~305.4g/mol Dosage FormFilm coated oral tabletStrength30mg per tabletPack Size4 tablets × 2 blistersApproval No.China NMPA H20213748Product Code86910323000123ManufacturerShenyang Hongqi Pharmaceutical Co., Ltd.Barcode6975167815429Storage ConditionsStore at 15–25°C; protect from moisture and lightIntended UseLaboratory research onlyMechanism of ActionDapoxetine is a short-acting SSRI that inhibits serotonin reuptake in the central nervous system, enhancing serotonin activity at the synapse. This action prolongs ejaculatory latency through modulation of sensory-spinal-brain circuits (e.g., 5HTA, 5HTB, 5HTC receptors).Research Applications & PharmacologyPremature Ejaculation (PE) Models: Significantly increases intravaginal ejaculatory latency time (IELT) when administered on-demand (30mg, sometimes 60mg) .Mechanistic CNS Studies: Helps explore serotonin signaling and ejaculatory control pathways .Pharmacokinetics: Rapid absorption, short initial half-life (1–2h), terminal half-life (~15–19h), mainly metabolized via CYP2D6 and CYP3A4, highly protein-bound (>99%) .Safety Profile & HandlingCommon Adverse Events: Nausea, headache, dizziness, diarrhea, insomnia .Serious Risks: Rare syncope observed shortly after dosing; caution advised in cardiovascular research.Handling: Store properly, use PPE, and discard expired products per lab protocol.Contraindications: Avoid in hepatic impairment models or when co-administered with strong CYP3A4 inhibitors or serotonergic drugs
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